Neuroglobin expression in ischemic stroke.
نویسندگان
چکیده
BACKGROUND AND PURPOSE We investigated whether neuroglobin, a neuronal protein that protects neurons from hypoxic-ischemic injury, is upregulated in ischemic stroke. METHODS Neuroglobin immunoreactivity was measured in brain tissue from control subjects and patients with ischemic stroke. RESULTS Neuroglobin was detected in several brain areas, and its expression was increased in the cortical peri-infarct region after stroke. CONCLUSIONS Ischemic stroke increases expression of the neuroprotective protein neuroglobin, suggesting neuroglobin may represent a novel target for stroke therapy.
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عنوان ژورنال:
- Stroke
دوره 41 3 شماره
صفحات -
تاریخ انتشار 2010